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KMID : 0378019710140060089
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New Medical Journal
1971 Volume.14 No. 6 p.89 ~ p.99
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Study on the Teratogenic Action of X-irradiation on Developing Rat Fetuses
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Abstract
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Ninety primiparous Sprague-Dawley ´albino rats were irradiated once with the doses ranging from 50r to 500r on the 7th, 9th, and 11th day of gestation. Some of the rats which received 200r of irradiation were injected spleen homogenate intraperitoneally.
Gross anomalies induced in fetuses, survival rates of fetuses, changes of fetal and maternal body weights, and numbers of corpus luteum of maternal ovary were studied on the 22nd day of gestation by hysterectomy and the following results were obtained.
The gross anomalies appeared in the fetuses of experimental `groups were reduced tail, curled tail, abnormal position and growth retardation of the limbs, anencephalus, abnormal beak and ventral hernia. Throughout the anomalies the abnormal tail was observed in the highest incidence.
The ninth day of gestation seems to be the most susceptible to the effect of irradiation in the critical period.
The earlier irradiation and the larger doses of irradiation they received, the more obvious decrease of survival rate and body weight of fetuses were observed, and in those animal groups the reduction of rates of maternal body weight gain was also recognized.
No direct relations between the numbers of corpus luteum and the irradiation were observed, and the spleen homogenate seemed not to be effective as a suppressor of the hazard of irradiation. The doses of 500r of X-irradiation induced maternal death or abortion in all cases.
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